The βA4 amyloid precursor protein binding to copper
نویسندگان
چکیده
منابع مشابه
Binding of F-spondin to amyloid- precursor protein: A candidate amyloid- precursor protein ligand that modulates amyloid- precursor protein cleavage
Amyloidprecursor protein (APP), a type I membrane protein, is physiologically processed by or -secretases that cleave APP N-terminal to the transmembrane region. Extracellular -cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subsequent -secretase cleavage in the transmembrane region of the C-terminal fragment induces secretion of small...
متن کاملCopper promotes the trafficking of the amyloid precursor protein.
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface. Here we report that copper, but not iron or zinc, promotes A...
متن کاملCOPPER PROMOTES THE TRAFFICKING OF THE AMYLOID PRECURSOR PROTEIN Authors:
Authors: Karla M. Acevedo, Ya Hui Hung, , Andrew H. Dalziel , Qiao-Xin Li , Katrina Laughton , Krutika Wikhe, Alan Rembach , Blaine Roberts , Colin L. Masters, , Ashley I. Bush 4 and James Camakaris. From Department of Genetics, Department of Pathology, Centre for Neuroscience, Mental Health Research Institute, The University of Melbourne, VIC, Australia; CSIRO Molecular and Health Technologies...
متن کاملCopper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion.
Previous studies have demonstrated that amyloid precursor protein (APP) can bind and reduce Cu(II) to Cu(I), leading to oxidative modification of APP. In the present study we show that adding copper to Chinese-hamster ovary (CHO) cells greatly reduced the levels of amyloid Abeta peptide (Abeta) both in parental CHO-K1 and in copper-resistant CHO-CUR3 cells, which have lower intracellular copper...
متن کاملamyloid precursor protein processing in alzheimer’s disease
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1994
ISSN: 0014-5793
DOI: 10.1016/0014-5793(94)00658-x